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Certainly most of these disorders are not associated with the devastating cognitive and behavioural problems seen with early childhood epileptic encephalopathies, such as West or Dravet syndromes.
However, it is clear that specific, and sometimes persistent, neuropsychological deficits in attention, language and literacy accompany many of the IFEs that, when multiplied by the large numbers affected, make up a significant public health problem.
What explains the age-related expression of these syndromes?
Why are EEG discharges and seizures so tightly locked to slow-wave sleep?
METHODS: A total of 12 children with intractable epilepsy associated with TSC who were treated with KD at our hospital between March 1, 2008 and February 28, 2015 were retrospectively enrolled.
PMID: 28775955 Abstract Author(s): Soyoung Park, Eun Joo Lee, Soyong Eom, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim Article Affiliation: Soyoung Park Abstract: BACKGROUND AND PURPOSE: In the present study, we reviewed the outcome of ketogenic diet (KD) use for the management of epilepsy in children with tuberous sclerosis complex (TSC).
The symposium led to the formation of international working groups under the umbrella of "Luke's Idiopathic Focal Epilepsy Project" to investigate various aspects of the idiopathic focal epilepsies including: semiology and classification, genetics, cognition, sleep, high-frequency oscillations, and parental resources (see They are fascinating disorders that hold many "treats" for both clinicians and researchers.For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy?Clearly, this is a situation ready for an overhaul in practice.Fundamental to understanding treatment is knowledge of aetiology.